![]() ![]() ![]() ![]() Working with other agents, he traced Mancuso's Internet address to a location near Pittsburgh, where he was later arrested.ĭuring their investigation, police officials had no way of knowing that the little girl in the photographs was Mancuso's adopted daughter. Sergeant Zaglifa says his instinct told him this man was an absolute danger to children. Posing as a pedophile, Chicago area police officer Mike Zaglifa discovered Mancuso in an online chat room. Back in the states, Masha expected a nice American home with a bedroom all her own. No phone calls were made to his ex-wife or to his biological daughter. What she didn't know was the adoption agency failed to properly check her new father's background. ![]() But nothing could have been farther from the truth. Mancuso seemed like her knight in shining armor. He visited Masha several times at the orphanage, took her to nice dinners, and bought her candy. After months of waiting, Mancuso traveled to Russia to meet his new daughter. He contacted a New Jersey adoption agency requesting information on 5-year-old Caucasian girls, and chose Masha from a videotape. Meanwhile, 41-year-old Matthew Mancuso, a divorced father in Pennsylvania, was looking for a little girl to adopt. Soon after recovering from her traumatic ordeal, Masha was sent to an orphanage where she prayed that a good family would come to rescue her. Her own mother tried to kill her when she was only 4 years old by stabbing her in the back of the neck with a kitchen knife. She was born in southern Russia to an alcoholic mother and a father she never knew. The Charles River " hairless" rat mutation is distinct from the hairless mouse alleles.At 13 years old, Masha has already survived the unthinkable. The Charles River (CR) " hairless" rat is one of the autosomal recessive hypotrichotic animal models actively studied in pharmacologic and dermatologic research. Despite its widespread use, the molecular basis of this monogenic mutation remains unknown, and the skin histologic features of this phenotype have never been described. However, the designation " hairless" has been used as an extension of the hairless mouse (hr) nomenclature on the basis of the clinical absence of hairs in both phenotypes. We present a description of the histopathologic changes in heterozygous and homozygous CR hairless rat mutants during the first month of life. The postnatal homozygous rat skin was characterized by abnormal keratinization of the hair shaft and formation of a thick and dense layer of corneocytes in the lower portion of the epidermal stratum corneum. This layer prevented the improperly keratinized hair shaft from penetrating the skin surface. Starting from the latest stages of hair follicle (HF) development, obvious signs of HF degeneration were observed in homozygous skin. This process was extremely rapid, and by day 12, mainly atrophic HFs with abnormal or broken hairs were present in the skin. Therefore, the mutation in the CR rat abrogates cell proliferation in the hair matrix and affects keratinocyte differentiation in the HF and interfollicular epidermis, a phenotype that is completely distinct from hr/hr. To test whether the CR rat harbored a mutation in the hr gene, we analyzed the coding region of this gene and consensus intron splice site sequences in mutant rats and found no mutation, further supporting phenotypic evidence that the hairless phenotype in CR rats is not allelic with hairless. ![]()
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